Most Grotesquely Incommensurate Actor Pairs

[David]

Who be your nominees?

Imagine them in a movie together, if you can.
I say:

DON KNOTTS & NADIA SIBIRSKAIA

http://www.tvguide.com/images/pgimg/don-knotts1.jpg

[petep9000]

Colleen Dewhurst and Jessica Simpson.

[carrie721]

ingrid bergman and jim varney

[mikeschmike]

Marjorie Main and Philip Seymour Hoffman